Stx1a Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comStx1a Polyclonal Antibody for Rat(Rattus norvegicus)

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Stx1a (Gene name),

Syntaxin-1A (Protein name ), STX1A_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Stx1a(Sap);

Protein name:

Syntaxin-1A;

Alternative:

Synaptotagmin-associated 35 kDa protein(P35A);Neuron-specific antigen HPC-1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with OTOF, SYTL4, VAPA, SYBU and LGI3. Found in a complex with VAMP8 and SNAP23. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity). Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds STXBP6. Found in a ternary complex with STX1A and SNAP25. Interacts with SLC6A4.

Function:

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

Subcellular Location:

Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane Single-pass type IV membrane protein Cell junction synapse synaptosome

Protein Attributes:

Sequence length:

288

Sequence:

50:

100:

150:

200:

250:

288:

TKKAVKYQSK | ARRKKIMIII | CCVILGIIIA | STIGGIFG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.9943

SMR:

P32851

STRING:

10116.ENSRNOP00000040699

Pfam:

PF05739

KEGG:

rno:116470

String:

P32851

Uniprot:

P32851

FOR

ELISA Kit for Rat Syntaxin-1A

Cat.:

E1124h

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96T

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ELISA Kit for Rat Syntaxin-1A

Cat.:

E1124r

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96T

ELISA Kit for Rat Syntaxin-1A

Cat.:

E1124b

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96T

ELISA Kit for Rat Syntaxin-1A

Cat.:

E1124m

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96T

CLIA Kit for Rat Syntaxin-1A

Cat.:

U1124r

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96T

CLIA Kit for Rat Syntaxin-1A

Cat.:

U1124h

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Manual:

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96T

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CLIA Kit for Rat Syntaxin-1A

Cat.:

U1124m

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96T

CLIA Kit for Rat Syntaxin-1A

Cat.:

U1124b

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96T

Polyclonal Antibody for Rat Syntaxin-1A

Cat.:

P1124Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Syntaxin-1A

Cat.:

P1124Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat Syntaxin-1A

Cat.:

P1124Rb-h

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40ug/0.2ml

Monoclonal Antibody for Rat Syntaxin-1A

Protein for Rat Syntaxin-1A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1."
Inoue A. , Obata K. , Akagawa K.
J. Biol. Chem.267:10613-10619(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 8-37 AND 44-102
tissue: Brain.
2.

"HPC-1 is associated with synaptotagmin and omega-conotoxin receptor."
Yoshida A. , Oho C. , Omori A. , Kuwahara R. , Ito T. , Takahashi M.
J. Biol. Chem.267:24925-24928(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-288;PROTEIN SEQUENCE OF 1-15 AND 95-113
tissue: Brain.
3.

"Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones."
Bennett M.K. , Calakos N. , Scheller R.H.
Science257:255-259(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-288;PROTEIN SEQUENCE OF 4-16 AND 31-56
tissue: Brain.
4.

"The syntaxin family of vesicular transport receptors."
Bennett M.K. , Garcia-Arraras J.E. , Elferink L.A. , Peterson K.E. , Fleming A.M. , Hazuka C.D. , Scheller R.H.
Cell74:863-873(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Syntaxin 12, a member of the syntaxin family localized to the endosome."
Tang B.L. , Tan A.E. , Lim L.K. , Lee S.S. , Low D.Y. , Hong W.
J. Biol. Chem.273:6944-6950(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNAP23
6.

"Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties."
Fasshauer D. , Antonin W. , Margittai M. , Pabst S. , Jahn R.
J. Biol. Chem.274:15440-15446(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A TERNARY COMPLEX WITH VAMP8 AND SNAP25
7.

"Regulation of the serotonin transporter by interacting proteins."
Haase J. , Killian A.M. , Magnani F. , Williams C.
Biochem. Soc. Trans.29:722-728(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC6A4
8.

"Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly."
Scales S.J. , Hesser B.A. , Masuda E.S. , Scheller R.H.
J. Biol. Chem.277:28271-28279(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STXBP6
9.

"Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18."
Tian J.H. , Das S. , Sheng Z.H.
J. Biol. Chem.278:26265-26274(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-188;INTERACTION WITH DAPK1 AND STKB1
10.

"Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution."
Sutton R.B. , Fasshauer D. , Jahn R. , Brunger A.T.
Nature395:347-353(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 180-262 IN COMPLEX WITH SNAP25 AND VAMP2
11.

"Structural analysis of the neuronal SNARE protein syntaxin-1A."
Lerman J.C. , Robblee J. , Fairman R. , Hughson F.M.
Biochemistry39:8470-8479(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 24-150
12.

"Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex."
Misura K.M.S. , Scheller R.H. , Weis W.I.
Nature404:355-362(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 27-248 IN COMPLEX WITH STXBP1
13.

"Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly."
Misura K.M.S. , Scheller R.H. , Weis W.I.
J. Biol. Chem.276:13273-13282(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 191-267
14.

"Crystal structure and biophysical properties of a complex between the N-terminal SNARE region of SNAP25 and syntaxin 1a."
Misura K.M.S. , Gonzalez L.C. Jr. , May A.P. , Scheller R.H. , Weis W.I.
J. Biol. Chem.276:41301-41309(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 191-267 IN COMPLEX WITH SNAP25
15.

"Three-dimensional structure of the complexin/SNARE complex."
Chen X. , Tomchick D.R. , Kovrigin E. , Arac D. , Machius M. , Suedhof T.C. , Rizo J.
Neuron33:397-409(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 191-253 IN COMPLEX WITH CPLX1; SNAP25 AND VAMP2;STRUCTURE BY NMR
16.

"High resolution structure, stability, and synaptotagmin binding of a truncated neuronal SNARE complex."
Ernst J.A. , Brunger A.T.
J. Biol. Chem.278:8630-8636(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 191-256 IN COMPLEX WITH SNAP25 AND VAMP2
17.

"Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A."
Fernandez I. , Ubach J. , Dulubova I. , Zhang X. , Suedhof T.C. , Rizo J.
Cell94:841-849(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 27-146

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